UHealth - University of Miami Health System

Mario A. Saporta, M.D.

Información general

Mario A. Saporta, M.D.



  • English
  • Spanish
  • Portuguese


  • Neurology (Psychiatry & Neurology)
  • Neuromuscular Medicine - Psych & Neuro


  • Assistant Professor of Neurology and Human Genetics
  • Co-director, Neuromuscular Medicine Fellowship
  • Director, Charcot-Marie-Tooth Center of Excellence
  • Director, Muscular Dystrophy Association Care Center
  • Principal Investigator, CMT Stem Cell Lab


2015 M.B.A.
Fundacao Getulio Vargas (FGV), Brazil
2012 Fellowship
NIH Inherited Peripheral Neuropathies Consortium
2011 Ph.D.
Universidade Federal do Rio de Janeiro/Wayne State Univ.
2010 Fellowship
Wayne State University, Detroit Medical Center
2007 MPhil
Universidade Federal do Rio de Janeiro/Centre Hospitalier Universitaire de Bicetre, France
2005 Residency
Universidade Federal do Rio de Janeiro, Brazil
2001 MD
Universidade Federal do Rio de Janeiro, Brazil



Mario Saporta, MD, PhD, MBA is an Assistant Professor of Neurology and Human Genetics at the Miller School of Medicine, University of Miami and an Adjunct Professor of Neurology and Clinical Neurophysiology at Universidade Federal Fluminense in Brazil. He is the director of the Muscular Dystrophy Association Care Center and the Charcot-Marie-Tooth Center of Excellence at the University of Miami where he coordinates a multidisciplinary clinical team to provide specialized care for patients with neuromuscular genetic disorders, with a focus on the inherited peripheral neuropathies (Charcot-Marie-Tooth Disease).


After completing his Neurology training in his home country of Brazil, Dr. Saporta underwent extensive training in neuromuscular disorders, with emphasis in the peripheral neuropathies, in centers in the United Kingdom (Institute of Neurology, University College London), France (Centre Hospitalier Universitaire de Bicêtre) and the US. He did his Neuromuscular/Clinical Neurophysiology fellowship at the Detroit Medical Center, home to the largest inherited neuropathy clinic in the world at the time, and was the first clinical research fellow of the NIH Inherited Neuropathies Consortium. Dr. Saporta has published extensively on the pathophysiology of different types of inherited peripheral neuropathies, using various disease models, including patients’ skin biopsies, mouse models and motor neurons from patients with CMT.


Dr. Saporta’s current research interest is the identification of mediators of axonal degeneration in inherited neuropathies using patient-derived neuronal cell lines. Axonal degeneration is the main driver of functional disability in patients with inherited neuropathies. Therefore, understanding the mechanisms behind axonal degeneration can provide investigators new targets for therapy development. Dr. Saporta’s lab creates disease modeling systems based on patients’ own cells and use them to better understand disease mechanisms and to look for new potential therapies.

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